Discover what makes Hampton Inn Santee-I-95 unique among Santee, SC hotels. Unwind in a spacious guest room and enjoy modern comforts to help you feel at home. Stay connected with free internet access. Enjoy our King rooms’ sofa bed and cocktail tables, allowing you to stretch out and fully relax. Take advantage of our double queen bedrooms, which offer a sitting area. Enjoy great value during your stay in our outdoor swimming pool and gym.